Leading Musculoskeletal Injury Care
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MIRROR Projects

Current Projects

Posts in Research Focus 1
Epidemiology of Musculoskeletal Injuries Trends in the MHS

MSI negatively affect military readiness, and accounted for 36.3% of all injury-related ambulatory visits in active duty service members in 2016. The high intensity of combat preparedness has elucidated that the greatest nonfatal threat to soldiers in non-deployed settings are MSI sprains, strains, and overuse injuries of the spine, back, and upper and lower extremities. In fact, the top five MSIs ranked by their contribution to the highest days of limited duty (DLD) contributed between 14 and 22 DLD per injury—or approximately 9 million DLD annually. While multiple epidemiological studies have been commissioned over the past 20 years to characterize the burden of specific MSIs in the MHS, information is fragmented and cannot be used to decrease DLD and predict the economic burden of MSIs in the MHS.

This study will provide critical MSI surveillance by developing a standardized, service-wide epidemiological report which will be used to understand the frequency and prevalence of injuries in the military. Data will be published quarterly and distributed to key stakeholders and sponsors to identify clinical and operational gaps in care.

A Retrospective Study of Service Members Enrolled in the Warrior Care and Transition Program

Throughout the campaigns in Iraq and Afghanistan, the Army has been determined to improve the health, welfare, and preparedness of wounded soldiers. The Warrior Care and Transition Program (WCTP) was established in 2004 and subsequently expanded and formalized in 2007 to serve as a comprehensive clinical rehabilitation program for the U.S. Army’s ill and/or injured soldiers. The primary focus of the WCTP is to fulfill the Army’s goal of enhancing wounded soldiers’ transitions back into the fighting force or into a veteran’s status, with full reintegration into the community. Since the WCTP’s inception in 2004, more than 77,000 soldiers have transitioned through the WCTP, and over 30,000 have returned to military duty. The program is designed to provide robust social and clinical care to active and reserve soldiers who require significant support, including case management, social work, and/or transition assistance. While entrance criteria have changed over the duration of the WCTP program, soldiers are generally required to have complex medical needs that will require significant care for a period of at least 3-6 months.

To meet the goal of comprehensive care, warrior transition units (WTU) integrate a diverse staff of primary care physicians, nurse case managers, rehabilitation specialists (OT/PT), social workers, counselors, and others. In addition to assistance with soldier transition, WTU programs also offer mental health and occupational therapy programs (Erickson, 2008). Coordinating efforts across all staff members is important to ensure the delivery of quality patient care. Recently, the Recovering Warrior Task Force, established by Congress in 2010, evaluated DoD wounded warrior services across the military. They synthesized 87 recommendations, which included efforts to better coordinate continuity of care in ways such as integrating IT systems and implementing more user-friendly electronic health records. At WTUs, a large amount of attention is placed on properly managing each patient’s electronic health record to maintain compliance.

WTU patient populations have changed in response to the nature of modern warfare and its intrinsic risks. As the needs of the Army and active combat operations have evolved over the past 10 years, the types of injuries and illnesses sustained by soldiers entering the WCTP have also changed, with the majority of entrants now falling into a disease NBI category. At present, there are fourteen WTUs co-located with MTFs, which reflects a >40% reduction in WTUs from the height of the program. Although military operations in Iraq and Afghanistan have declined significantly, resulting in fewer wounded warriors returning home and a decline of the WCTP population (currently around 2,600 soldiers), the Army is committed to supporting and caring for transitioning soldiers and their families, and remains flexible to changes in the future population.

To the best of our knowledge, this is the first study of its kind to characterize the patient population within the WCTP. Despite the WCTP’s focus on effectively coordinating efforts, there has been minimal systematic research on the WCTP, and the potential exists to identify relevant trends and anomalies that may inform decision-makers within the medical command (MEDCOM) and WCTP. Certain patterns and anomalies may even prove relevant to other military medical efforts and highlight clinical gaps. There are several large, well-maintained databases that track WCTP patients and are available for records-based research (provided the requisite data use agreements and institutional oversight), but this must be evaluated by MIRROR.

Ultrasound Evaluation of Anatomic Variations of the Median Nerve and Carpal Tunnel

Carpal tunnel syndrome (CTS) is the most common peripheral neuropathy and occurs in 3-6% of adults in the United States. While many patients with CTS respond to conservative treatment, there is strong evidence that supports operative management. Post-op complications, while rare, are frequently due to nerve injury and include post-operative pain, dysesthesia, paresthesia, and formation of painful neuromas. Variations in the anatomy of the median nerve increases the risk of damage to branches. Various anatomical variants in the carpal tunnel have been suggested to contribute to median nerve compression, including bifurcation of the median nerve, persistent medial artery, extra tendons within the carpal tunnel, and palmaris longus variations.

The purpose of the study is to utilize ultrasound to investigate the prevalence of variations in the anatomy of the median nerve and surrounding structures, to compare the rate of variation in individuals with carpal tunnel syndrome symptoms verses those without, and to evaluate if specific anatomic variations are more prevalent in different patient populations.

Establishing Limits of Normal for Important Muscles and Tendons of the Rotator Cuff Using Ultrasound

Ultrasound (US) is frequently used to diagnose shoulder pathology, and can be used in an office setting to quickly and cost-effectively assess the quality of the rotator cuff musculature. Diagnostic imaging of the rotator cuff muscle quality can help determine prognosis as well as appropriate management. For instance, we know that maximum cross-sectional area (CSA) of the rotator cuff muscles is closely related to that muscle’s isokinetic strength and predicts rotator cuff pathology and surgical outcomes. Fatty degeneration of the rotator cuff is predictive of deficits in strength and function, specifically for abduction, external rotation, and internal rotation. Though the thickness or CSA of a rotator cuff can easily be obtained, there is much variation in in a healthy rotator cuff muscle’s CSA based on patient age and gender, which makes it difficult to deduce whether there is pathology based on only CSA, making a ratio involving muscle size more predictive of pathology than CSA only.

Literature suggests that use of ratios of rotator cuff CSA or thickness may be predictive of rotator cuff pathology than thickness or CSA alone, and that supraspinatus and infraspinatus size can be reliably measured under ultrasound. Therefore, we propose establishing normative measurements of three different ratio involving the rotator cuff muscles: the trapezius : supraspinatus thickness ratio, the supraspinatus : infraspinatus CSA ratio, and the infraspinatus : teres minor CSA ratio.

Chemical and Cellular Characterization of Hemarthroses after Traumatic Knee Injuries in Active-Duty Military Personnel

Knee injuries, such as those to the meniscus or anterior cruciate ligament (ACL), are common in the military due to lower-extremity demands placed on soldiers. These injuries are difficult to heal and predispose soldiers to the development of osteoarthritis (OA), which can limit their function and quality of life. Surgery is not always the preferred course of treatment, and is not completely effective in preventing post-traumatic OA when performed. It is hypothesized that the acute inflammatory reaction to these injuries plays a role in the development of OA via exposure of synoviocytes to noxious stimuli.

The primary objective of this study is to evaluate the biochemical and cellular composition of hemarthroses after acute knee injuries. Secondarily, we seek to create a platelet-rich plasma (PRP) product using hemarthroses collected after aspiration and characterize the biochemical and cellular composition of the product. This study will provide the preliminary data needed to design, fund, and implement a future interventional study, which will use the PRP product in a clinical trial for acute knee soft-tissue injuries.

Development of Persistent Musculoskeletal Pain in the Military: The Prediction of Outcomes, Utilization, and Readiness after Surgery (POURS) Cohort for Knee and Shoulder

Chronic and persistent pain after orthopaedic injury is one of the primary barriers to readiness across all military services. Currently, the ability to accurately predict which military service members will develop chronic and persistent pain conditions after surgery for an orthopaedic injury is lacking. This information will allow the medical team to intervene early, or perhaps reconsider surgical options for those who will be known to have poor outcomes. This study is focused on current active duty military service members. It is imperative that we understand how to minimize lost work days and disability in these specific beneficiaries. Even modest reductions in persistent pain and disability will improve patient-centered outcomes and reduce cost for the Department of Defense.

This study will develop and validate an innovative predictive framework to provide clinical point-of-care algorithms to accurately identify 12-month outcomes related to military readiness, clinical outcomes, and healthcare utilization to improve prediction accuracy of who will do well post-surgery and who will not.

Military Orthopaedics Tracking Injuries and Outcomes Network (MOTION) Support

Musculoskeletal injuries (MSKI) remain the largest source of disability, readiness impairment, non-deployable status, and separation within the United States (US) Military. The Department of Defense (DoD) pays $3.7 billion annually for MSKI care; while the Department of Veterans Affairs pays in excess of $5.5 billion annually for MSKI related compensations. The Military Orthopaedics Tracking Injuries and Outcomes Network (MOTION) is the first tri-service, multi-center DoD-wide initiative to optimize military-specific and clinically-relevant patient outcome metrics for MSKI.

MOTION has more than 15,000 enrolled patients who received various orthopaedic treatment interventions on upper extremity, lower extremity, or spine MSKI. Validated patient reported outcome data are collected as part of the standard of care during the pre-operative visit and during follow-up visits at 6 weeks, 6 months, 12 months, 2 years, 5 years, 10 years, 15 years, and 20 years after surgery. Patient data are then linked with clinical provider intra-operative assessments and other relevant clinical data to optimize patient outcomes, improve procedural efficiency, and increase healthcare value and cost effectiveness.

Future outcomes-driven changes require advanced predictive models and integration within the DoD. MOTION will develop, conduct, and disseminate original and innovative military relevant clinical research focusing on outcomes and return to duty following MSKI. This research will result in improved military health and readiness, the development of improved evidence-based clinical practice guidelines, mitigating long-term physical detriments following injury, promoting greater military career longevity, and improved post-military service quality of life. Under MIRROR, the MOTION platform will be enhanced with additional analytical resources to improve military medical readiness, enhance value-based healthcare improvement, and support continuous quality improvement.

Sites w/ MIRROR Personnel:

-Walter Reed National Military Medical Center

-Brooke Army Medical Center

-Naval Medical Center San Diego

-Tripler Army Medical Center

-US Air Force Academy

-US Naval Academy

Sites Utilizing Remote Coordinator Support:

-Eglin Air Force Base

-Landstuhl Regional Medical Center

-Naval Medical Center Camp Lejeune

-Naval Medical Center Portsmouth